DataTables is a widely-used, open-source jQuery plugin that enhances HTML tables with advanced interaction features. It enables functionalities such as pagination, instant search, and multi-column sorting, making it easier to manage large datasets in web applications. DataTables is highly customizable, supporting various extensions and plug-ins to add capabilities like export buttons and complex data handling. It is particularly popular for its ease of integration and extensive documentation, which allows developers to create responsive and dynamic tables with minimal effort.