I know many smaller users have deployed Rootstock but what about large manufacturers?

Rootstock is purpose-built for mid-market manufacturers ($15M-$1B) looking to streamline and scale manufacturing teams using one system and one data model. Another common use case scenario typical of larger manufacturers is a two-tier ERP strategy where they keep financial teams and corporate operations on a “corporate” ERP (1st tier) and are looking for stronger manufacturing operations capabilities with a manufacturing ERP such as Rootstock reporting from a facility or division scope (2nd tier).